Principal Scientists, BioMedicine Design – Pfizer

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Job Description

The successful candidate will play a key role in building state of the art high throughput B cell cloning and sequencing pipeline in the cell-based antibody discovery group. The incumbent will collaborate with scientists within the organization to actively improve and drive therapeutic antibody discovery efforts by developing and employing state of the art B cell repertoire analysis and sequencing technologies. She/He will also participate in driving strategies and developing innovative technologies around cell-based therapeutic antibody discovery to enable deep antibody repertoire screening from immunized hosts. Primary responsibilities include but not limited to:

  • Establishing efficient molecular cloning of immunoglobulin genes work flow on various species (e.g. hybridoma, single B cell)
  • Establishing and optimizing rapid NGS workflow to study Immunoglobulin repertoire
  • Analyzing NGS data
  • Driving novel antibody discovery technology development
  • Applying appropriate improvements to biotherapeutic discovery and generate positive impact
  • Driving biotherapeutic drug development programs
  • Collaborating with lead generation team to develop and drive best-in-industry discovery engine


  • Ph.D. in immunology, molecular biology, virology, or computational biology with 2-4 years of industrial experience.
  • Proven publication record in top tier journals
  • Strong proven molecular biology skills
  • Proven expertise in NGS Ig amplicon library generation and NGS sequencing work flow
  • Hands-on experience in Illumina Sequencing platform
  • Proven expertise in single B cell cloning in various species
  • Knowledge and proven record of developing state of the art antibody discovery platforms
  • Strong organizational and project management skills
  • Strong oral and written communication skills


  • Expertise in immunoglobulin alignment and sequence analysis packages
  • Experience in molecular biology lab automation and process integration
  • Expertise in single cell cloning and sequencing
  • Experience in microfluidics is a plus
  • Experience in proteomic is a plus
  • Experience in applying proteomic in antibody discovery a plus
  • Experience in various computational programming skills is a plus
  • Working experience in R, Perl, and other statistical packages is a plus

EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status.  Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA.   Pfizer is an E-Verify employer.

Sunshine Act
Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure.  Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act.  Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government.  If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

Apply at using Job ID # 4718318